DIM3X provides 200 mg of DIM a day. We review what DIM does to estrogen metabolism, the lack of testosterone evidence in men, the tamoxifen interaction and other cautions.
DIM3X provides 200 mg of DIM (diindolylmethane) a day, an amount within the range used in human studies, where DIM shifted how estrogen is broken down. Those studies were mostly in women. We found no trial of DIM3X itself and no good evidence that DIM raises testosterone or improves symptoms in men. DIM can also raise SHBG and interacts with tamoxifen.
DIM is formed from compounds in cruciferous vegetables such as broccoli. In human studies at 100 to 300 mg a day, it shifted estrogen metabolism toward 2-hydroxyestrone relative to 16-alpha-hydroxyestrone. The largest trial (130 women on tamoxifen, 150 mg twice daily for 12 months) also found higher SHBG, a protein that binds testosterone, which may lower free testosterone. We found no human trial showing DIM raises testosterone in men.
DIM3X contains 200 mg of DIM per daily capsule, plus AstraGin, BioPerine and vitamin E (amounts of AstraGin and BioPerine aren't stated). In a small 2008 dose-finding study, single doses up to 200 mg were well tolerated, while 300 mg added side effects without raising blood levels. AstraGin and BioPerine have supplier-funded absorption studies on other nutrients, not on DIM.
Don't use DIM with tamoxifen or during treatment for a hormone-sensitive cancer without your oncologist's approval. It is not for pregnancy, breastfeeding or trying to conceive, and it may affect drugs cleared by the liver enzyme CYP1A2. Tell your doctor you take it before hormone blood tests. Common effects include darker urine, headache, nausea and loose stools. DIM3X has a 67-day money-back guarantee, but the official page describes the return conditions inconsistently, so confirm them first.