Spermidine is the most evidence-backed autophagy supplement available. Complete guide — mechanism, published human evidence, correct dose and what to look for.
Spermidine is a naturally occurring polyamine that stimulates autophagy — the cellular self-cleaning process. Published human research associates higher spermidine intake with reduced mortality. It is the most evidence-backed autophagy-targeting supplement available. GenuinePurity Spermidine scores 9.0/10 on WellnessChecked.
Spermidine is a polyamine — a class of organic compounds with multiple amine groups. It is present in all living cells and is involved in cell growth, proliferation and survival. Its most studied longevity-relevant function is autophagy induction — stimulating the cellular self-cleaning process.
Autophagy (from the Greek for 'self-eating') is the cellular process of degrading and recycling damaged proteins, organelles and cellular debris. Efficient autophagy is associated with healthy cellular function and longevity. Declining autophagy with age allows accumulation of cellular damage associated with aging and disease.
The Bruneck cohort study (Kiechl et al., 2018) followed 829 participants for 20 years, finding that higher dietary spermidine intake was independently associated with reduced all-cause mortality. A separate supplementation study confirmed spermidine's ability to stimulate autophagy in peripheral blood mononuclear cells of older adults.