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Does GenF20 Plus Actually Work? HGH Support Evidence Reviewed
WellnessChecked Editorial · October 2026
Does GenF20 Plus Actually Work? HGH Support Evidence Reviewed
GenF20 Plus has one small product trial on IGF-1. We review what it did and didn't show, the ingredient doses, the 67-day guarantee terms and who should avoid it.
⚡ Quick AnswerLast Reviewed: October 2026
The evidence is weak. GenF20 Plus is our top pick among HGH-releaser supplements, and it is one of the few HGH releasers tested as a finished product. But in its one small trial, the rise in IGF-1 was not statistically significant versus placebo across all participants, growth hormone wasn't measured, and there were no significant differences in body fat, energy, sleep or libido.
The Product Trial
In a 2015 randomized, placebo-controlled trial (Sonawane et al.), 70 adults aged 35 to 65 in India were assigned to GenF20 Plus or placebo for 12 weeks, taking two tablets plus 2 mL of liquid under the tongue twice daily; 61 finished. Across all participants, IGF-1 (a blood marker linked to growth hormone) rose by 13.46 ng/mL on GenF20 Plus versus 6.35 ng/mL on placebo, a difference that was not statistically significant.
The often-quoted 28% rise comes from a later analysis of participants aged 40 and over, adjusted for baseline differences. Body fat, lean mass, waist, memory, libido, energy and sleep did not differ significantly from placebo. The trial was small and exploratory, it was run by a contract research firm with outside financial support, and it hasn't been independently repeated.
GenF20 Plus contains no growth hormone. Mayo Clinic says research does not show that supplements claiming to raise HGH work, and the FTC said in 2005 it knew of no competent evidence that HGH pills or sprays raise growth hormone. For how these products compare with prescription treatment, see HGH supplements vs HGH injections.
Key Ingredients (tablet, per serving)
L-arginine 130 mg — a fraction of the multi-gram amounts used in arginine growth hormone research
L-glutamine 115 mg; L-glycine, L-lysine and L-tyrosine 100 mg each — small amounts
GABA 50 mg — may lower blood pressure
Bovine colostrum 50 mg, deer antler velvet 50 mg and anterior pituitary powder 30 mg — animal-derived; not vegetarian
Astragalus root extract 60 mg, plus smaller amounts of other amino acids and chromium; the oral spray's ingredients aren't listed on the official site
GenF20 Plus comes with a 67-day guarantee from delivery, with conditions (opened and unopened boxes must reach the warehouse within 67 days; shipping isn't refunded). Our GenF20 Plus side effects guide covers who should avoid it.
The evidence is weak. In its one small trial, the IGF-1 rise was not statistically significant versus placebo across all participants; a positive result appeared only in a later analysis of people aged 40 and over. Growth hormone wasn't measured, and body fat, energy and sleep did not change versus placebo.
The product trial ran 12 weeks and found no significant difference from placebo in energy, sleep or body composition over that time. The guarantee window is 67 days from delivery. To keep the refund option, decide by about day 55 so returns arrive within 67 days of delivery.
Side effects weren't a problem in its small trial, but it isn't for pregnancy, breastfeeding, under-18s or anyone with a history of cancer unless their oncologist agrees. L-arginine and GABA may lower blood pressure, and it contains deer antler velvet, colostrum and pituitary powder. Ask your doctor if you take blood pressure, diabetes, thyroid or blood-thinning medicines.
The guarantee applies in practice to orders from the official website. It runs 67 days from delivery, shipping isn't refunded and there is one refund per customer.
GenF20 Plus has one small product trial (with a non-significant overall IGF-1 result); HyperGH 14x has none. HyperGH 14x lists larger amino acid amounts and a spray containing Mucuna pruriens. See our comparison page for details.
Disclaimer: For informational purposes only. All products are dietary supplements — not medicines. Not intended to diagnose, treat, cure or prevent any disease. These statements have not been evaluated by the FDA. Individual results may vary. Always consult a qualified healthcare professional. We earn affiliate commissions via links on this page. Full disclaimer →
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