Top pick: HGH-releaser supplements (weak evidence)Product trial published67-day guarantee
GenF20 Plus Review — Ingredients, Evidence & Verdict
Written by the WellnessChecked Editorial Team. We checked the formula, the guarantee terms and the published research on its ingredients.
✍️ WellnessChecked Editorial Team✅ Sources listed on this page
HGH-releaser supplements
Best for
1 product trial
Evidence
67-Day
Guarantee
Scroll down to read our full analysis, including ingredient breakdown, pros & cons, and where to buy safely ↓
📋 Editorial & Affiliate Disclosure: This review was written by the WellnessChecked editorial team. We only cover products from brands we have affiliate relationships with, so our top picks are the best of the products we cover, not of every product on the market. We earn a commission if you purchase through our links — paid by the manufacturer at no extra cost to you. We aim to describe every product accurately, including its limits. Read about our methodology → | Full disclaimer →
Our top pick among HGH-releaser supplements
⚡ Quick AnswerLast Reviewed: October 2026
✅ Updated October 2026: claims rechecked against the official site and published research
GenF20 Plus is our top pick among HGH-releaser supplements. It's an amino acid tablet plus oral spray from Leading Edge Health, and one of very few HGH supplements tested in a published double-blind trial. That 2015 trial (61 adults, 12 weeks) found no significant IGF-1 increase versus placebo overall; the advertised 28% rise comes from a post hoc analysis of people aged 40 and over. It contains no growth hormone and comes with a 67-day money-back guarantee with strict conditions.
The one published trial of GenF20 Plus randomized 70 adults aged 35–65 in India; 61 finished. After 12 weeks, IGF-1 rose by about 13.5 ng/mL on GenF20 Plus versus 6.4 ng/mL on placebo, a difference that was not statistically significant. A significant result appeared only in a post hoc analysis of people aged 40 and over. Body fat, lean mass, energy, sleep, memory and libido didn't differ from placebo, and growth hormone itself wasn't measured. The trial was small, funded through a third-party company, and hasn't been repeated.
GenF20 Plus suits a healthy adult who wants to try an HGH releaser with a real refund policy and is comfortable with modest expectations. Its one trial did not show a significant IGF-1 increase versus placebo overall, and it never measured growth hormone or showed changes in body fat, energy or sleep.
GenF20 Plus is an amino acid-based 'HGH releaser' (tablets plus oral spray) from Leading Edge Health. It contains no growth hormone. Its one published trial found a larger IGF-1 rise than placebo, but the difference wasn't statistically significant across all participants, and it found no difference in body fat, energy or sleep.
In this review we go through what's in GenF20 Plus, what its trial actually found, the side effects and the guarantee terms. Read the full analysis below before making a decision.
GenF20 Plus at a Glance
Ingredients
Amino acids, herbs, chromium and animal-derived extracts. Tablet amounts are published but far below research doses; the spray's contents aren't listed.
Evidence
One small 12-week trial of the product (61 completers). Main IGF-1 result not significant; the positive result is from a post hoc subgroup.
Transparency
Maker, company addresses and tablet amounts published. Written guarantee terms. Spray ingredients not disclosed.
Safety
Mostly mild stomach side effects in the trial, at a similar rate to placebo. Several ingredients can interact with blood pressure, diabetes and thyroid medicines.
Value
About $58–70 a month on the official site (October 2026).
We compare products on ingredients and doses, published evidence, transparency and guarantee terms, safety and value. How we review →
What Is GenF20 Plus?
GenF20 Plus is a two-part system: enteric-coated tablets plus an oral spray, sold by Leading Edge Health. As of October 2026 the official site lists these tablet amounts per serving: L-arginine 130 mg, L-glutamine 115 mg, L-glycine, L-lysine and L-tyrosine 100 mg each, astragalus root extract 60 mg, deer antler velvet 50 mg, GABA 50 mg, bovine colostrum 50 mg, L-valine 40 mg, anterior pituitary powder 30 mg, phosphatidyl choline 25 mg, L-ornithine 25 mg and GTF chromium 0.1 mg. The spray's ingredients aren't listed on the official site. It contains no growth hormone.
*Dietary supplement. Not intended to diagnose, treat, cure or prevent any disease. Statements not evaluated by the FDA.
Active Ingredients — Full Scientific Breakdown
What each listed ingredient is and what human studies have looked at. Where the maker doesn't disclose doses, we can't say whether they match the studies:
L-Arginine (130 mg per serving, per the official site)Amino Acid
Arginine has raised growth hormone in studies using several grams; GenF20 Plus lists 130 mg, and no study shows an effect at that dose.
L-Glutamine (115 mg per serving, per the official site)Amino Acid
Evidence that oral glutamine raises growth hormone is limited and used far higher doses than the 115 mg here.
L-Ornithine (25 mg per serving, per the official site)Amino Acid
Arginine-ornithine combinations have been studied at gram doses; there is no evidence for an effect at the 25 mg in GenF20 Plus.
Oral Spray (ingredients not listed)Undisclosed
The official site does not list the spray's ingredients or amounts, so we can't confirm what it contains or at what dose. Check the spray's own label.
Deer Antler Velvet, Colostrum and Pituitary PowderAnimal-Derived
Deer antler velvet (50 mg), bovine colostrum (50 mg) and anterior pituitary powder (30 mg, animal source not stated). There's no good evidence these raise growth hormone in people. Deer antler velvet may contain IGF-1, which is banned in tested sport. Not vegetarian, and not for people with a dairy allergy.
Also in the tablets: L-glycine, L-lysine and L-tyrosine (100 mg each), astragalus root (60 mg), GABA (50 mg), L-valine (40 mg), phosphatidyl choline (25 mg) and GTF chromium (0.1 mg). A separate official ingredients page also names L-isoleucine and Tribulus terrestris, without amounts. Arginine and GABA may lower blood pressure; arginine and chromium may lower blood sugar.
📋 Our Editorial Concerns
In the interest of balance, here are the limitations of GenF20 Plus that we think buyers should know:
→The trial's main IGF-1 result was not statistically significant; the advertised 28% rise comes from a post hoc subgroup of people aged 40 and over
→Tablet doses are a small fraction of the amounts used in growth hormone research
→The oral spray's ingredients aren't listed on the official site
→The guarantee is strict: empty boxes must arrive within 67 days of delivery, shipping isn't refunded, and it's one refund per customer
Results Timeline: What to Expect
This timeline isn't based on tracked customer outcomes. Here's what the one published trial measured, and what isn't known:
1
Weeks 1–4: No Reliable Data
The trial found no difference from placebo in sleep or energy at 12 weeks, and there's no data on early effects.
2
Month 2: Not Measured
Skin and recovery were not measured in the product's trial; there is no evidence for a two-month timeline.
3
Week 12: When the Trial Measured Results
The 12-week trial found no difference from placebo in body fat or lean mass. IGF-1 rose more than on placebo, but not significantly across all participants.
⚠️ Important: There's no reliable evidence that GenF20 Plus produces noticeable changes on any timeline. The price is not backed by product-specific evidence; if you try it, the 67-day money-back guarantee lets you get your money back, but conditions apply (see below).
🔬 What the Evidence Actually Shows
Trial of the product itself: One randomized, double-blind trial (Sonawane et al., 2015): 61 adults aged 35–65, 12 weeks. IGF-1 rose more than on placebo, but not significantly overall; the 28% figure is from a post hoc subgroup of people 40 and over. No difference in body fat, energy, sleep or libido. Small, funded through a third-party company, and not repeated.
Ingredients: Arginine and related amino acids have raised growth hormone only at multi-gram doses. Mayo Clinic says research doesn't show that supplements claiming to raise HGH work.
Doses on the label: Tablet amounts are on the official site (for example, L-arginine 130 mg per serving). The spray's ingredients and amounts aren't listed.
Guarantee: 67 days from delivery. Try it for 60 days, then return the two opened empty boxes plus any unopened ones so they arrive within 67 days of delivery. Shipping isn't refunded, duties and taxes must be paid, and it's one refund per customer.
✓One of few HGH releasers tested in a published placebo-controlled trial
✓Tablet ingredient amounts are published
✓Written 67-day money-back guarantee
✓Trial reported mostly mild side effects at a similar rate to placebo
✗ Considerations
✗Main trial result was not significant; the 28% figure is a post hoc subgroup
✗No difference from placebo in body fat, energy, sleep or libido
✗Oral spray ingredients not listed on the official site
✗Low ingredient doses; animal-derived ingredients
⚠️ Who Should NOT Take GenF20 Plus
✗Anyone under 18 years of age
✗Pregnant or breastfeeding women (no safety data; astragalus showed fetal toxicity in animals)
✗Anyone with a history of cancer, unless their oncologist agrees (it is marketed to raise GH and IGF-1)
✗Anyone on blood pressure drugs, nitrates, ED drugs, diabetes medicines, levothyroxine, blood thinners or potassium-sparing diuretics, unless a doctor says it's OK
✗Vegetarians, people with a dairy allergy and drug-tested athletes (deer antler velvet, bovine colostrum and pituitary powder)
This list isn't complete. Check with a doctor or pharmacist before taking any supplement.
Is GenF20 Plus Safe?
In its one 12-week trial, side effects were mostly mild heartburn and stomach pain, at a similar rate to placebo. Like any supplement, it can cause side effects and interact with medications.
✓ What the Trial Found
In its one 12-week trial (61 completers), side effects were mostly mild heartburn and stomach pain at a similar rate to placebo, with one headache and one skin eruption. No serious adverse events were reported, but the trial was too small and short to detect rare reactions.
⚠️ Consult Your Doctor If:
● You take blood pressure drugs, nitrates or ED drugs
● You take diabetes medicines, levothyroxine or blood thinners
● You have a history of cancer
● You are pregnant, breastfeeding or under 18
Where to Buy GenF20 Plus Safely
We suggest buying from the official website, so you can:
✓ Buy directly from the maker (we have not verified counterfeit listings, but marketplace purchases are generally not covered by the manufacturer's guarantee)
✓ Qualify for the 67-day money-back guarantee (conditions apply)
🛡️ 67-Day Money-Back Guarantee (seller's terms apply) · Official manufacturer only
*Individual results vary. Not intended to diagnose, treat, cure or prevent any disease. These statements have not been evaluated by the FDA. Full disclaimer →
🛡️ Final Verdict: GenF20 Plus
GenF20 Plus suits a healthy adult who wants to try an HGH releaser with a real refund policy and is comfortable with modest expectations. Its one trial did not show a significant IGF-1 increase versus placebo overall, and it never measured growth hormone or showed changes in body fat, energy or sleep.
Best for: healthy adults who want to try an HGH releaser with a real refund policy and modest expectations.
Not for: anyone expecting results like prescription growth hormone, anyone with a history of cancer, or anyone on blood pressure, diabetes or thyroid medicines without a doctor's OK.
*These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure or prevent any disease. Individual results may vary. Full disclaimer →
Yes, one. A 2015 double-blind, placebo-controlled trial found a larger IGF-1 rise on GenF20 Plus than placebo, but the difference was not statistically significant across all 61 participants; a significant result appeared only in a post hoc analysis of people aged 40 and over, and growth hormone itself was not measured. It also found no difference from placebo in body fat, energy or sleep.
It's marketed to both men and women, and its trial included both. It isn't suitable during pregnancy or breastfeeding.
In its 12-week trial, side effects were mostly mild heartburn and stomach pain, at a similar rate to placebo. Arginine, GABA and chromium can interact with blood pressure, diabetes and thyroid medicines, and it contains animal-derived ingredients. Check with your doctor if you take prescription medication.
Buy from the official website, where the 67-day guarantee applies. We have not verified counterfeit listings, but marketplace purchases are generally not covered by the manufacturer's guarantee.
Anyone under 18, pregnant or breastfeeding women, people with a history of cancer, and anyone on blood pressure, nitrate, ED, diabetes, thyroid or blood-thinning medicines should talk to a doctor first. It's also not suitable for vegetarians or people with a dairy allergy.
Also Consider
Other supplements in Anti-Aging & Longevity you may want to compare:
Please note: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any supplement. Individual results vary. *Not evaluated by the FDA. Not intended to diagnose, treat, cure or prevent any disease.
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