Which VigRX formula fits your goal? Side-by-side analysis by the WellnessChecked editorial team.
✍️ WellnessChecked Editorial Team✅ Side-by-Side Comparison📅 Updated October 2026
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⚡ Quick AnswerLast Reviewed: October 2026
VigRX Plus is our top pick among male sexual-health supplements: an herbal blend with one small published placebo-controlled trial of the product. VigRX Nitric Oxide is a simpler L-citrulline and L-arginine formula; those amino acids have some evidence for mild erection problems at gram doses, but the product's doses aren't disclosed and it hasn't been studied.
Neither product is a treatment for erectile dysfunction; see a doctor about persistent symptoms.
⚡ Quick Verdict
We prefer VigRX Plus, our top pick among male sexual-health supplements, because the product itself has a published trial (75 men, 12 weeks, better erection scores than placebo). That trial was small and used an older, higher-dose formula. VigRX Nitric Oxide may suit men who specifically want an amino-acid formula, but its doses are unknown.
A VigRX-brand capsule described as a mixture of L-citrulline and L-arginine, amino acids the body uses to make nitric oxide. Doses aren't disclosed and the product hasn't been clinically tested.
An herbal blend (damiana, Asian red ginseng, muira puama, hawthorn, catuaba, saw palmetto, ginkgo and Bioperine) from Leading Edge Health. It's one of the few products in this category with a published placebo-controlled trial of the product itself: 75 men, 12 weeks, better erection scores than placebo. The trial was small and used an older, higher-dose formula.
VigRX Plus is our top pick among male sexual-health supplements, with modest expectations given its one small trial. Buy from the official site so the 67-day guarantee applies and to avoid counterfeits.
We prefer VigRX Plus because the product has a published placebo-controlled trial; VigRX Nitric Oxide hasn't been studied and doesn't disclose its doses.
VigRX Plus is an herbal blend (damiana, Asian red ginseng, muira puama, hawthorn, catuaba, saw palmetto, ginkgo and Bioperine). VigRX Nitric Oxide is described as a mixture of L-citrulline and L-arginine; its doses aren't disclosed.
We don't recommend combining them without a doctor's advice. Both can affect blood pressure and blood flow (L-arginine in one; hawthorn and ginkgo in the other), which matters if you take heart or blood pressure medicines.
From the official VigRX Plus website. Its guarantee requires empty containers to reach the warehouse within 67 days of delivery, excludes shipping and is limited to one order per customer; the terms don't say they cover third-party purchases. Counterfeits with hidden ED drugs have been found, which is another reason to buy direct.
L-arginine can lower blood pressure further with nitrates, ED drugs or blood pressure medicines, and Mayo Clinic advises against it after a recent heart attack. VigRX Plus contains ginkgo and ginseng, which can interact with blood thinners and diabetes medicines. Persistent erection problems can be an early sign of heart disease, so see a doctor.
Disclaimer: This comparison is produced by the WellnessChecked editorial team. None of the products mentioned are medicines. Not intended to diagnose, treat, cure or prevent any disease. These statements have not been evaluated by the Food and Drug Administration. Individual results may vary. Always consult a qualified healthcare professional before starting any supplement program. We earn affiliate commissions on purchases made via links on this page — at no extra cost to you. Full disclaimer →
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